Southwest Alaska includes a large diverse area from Cook Inlet to the western Bering Sea over 500 miles away. This large area includes coastal, forest, swamp, and mountain environments. This area is home to over 53,000 people, most of whom are Alaskan Natives of the Yupik, Alutiiq, and Aleut groups. The population is scattered into about 121 villages and towns. Very few of the villages are linked by road. Most people travel by air, boat, or snow machine in the winter. SW Alaska is one of the richest salmon fishing areas in the world. It also has one of the highest concentrations of brown bears.

AMC started work in SW Alaska in 1998 when a missionary couple began a houseboat ministry on the Kuskokwim River. This ministry has grown into Vacation Bible School (VBS) being provided to about 14 villages each summer. Most of the VBS teams come from the lower 48 states. They spend from one to two weeks in the SW providing ministry to between 30 to 200 children in each village. These teams are coordinated by a full time AMC missionary with a focus on the SW. AMC works closely with the local schools, village government and churches. These VBS programs are eagerly anticipated by the village children each year.